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脏器损伤与防护研究室
编辑:     发布日期:2017-03-31    来源:

一、团队简介

随着放射治疗临床适应证的扩展,放射性脏器损伤发生率也增加。目前, 放射性损伤是制约放射治疗技术进一步发展的瓶颈。在国家自然科学基金、江苏省科学自然基金等基金资助下,本科研团队利用肺离体灌流技术平台和HO-1基因条件敲除小鼠模型,结合实验室研究特色和业务特长,研究探索大剂量放疗射线对正常组织损伤的毒理机制及其防治措施,主要开展以下研究工作有:1血红素加氧酶-1对放射性肺炎的保护作用及机制研究;2放射性肝病标志性蛋白的分析和鉴定;3非编码RNA与肺癌及其放射性肺炎的相关性。

二、团队负责人简介

庞庆丰,男,1972.03生,博士。

研究方向

肺损伤的防治

学习经历

2005/9~2008/7,南京医科大学,药理学,博士

2000/9~2003/7,南京医科大学,病理学与病理生理学,硕士

1989/9~1994/7,徐州医学院,临床医学,学士

科研与学术工作经历

2013/4~至今,江南大学医学院,基础医学系,教授

1994/9~2013/3,徐州医学院,基础医学院,助教、讲师、副教授、教授

2012/1~2014/12,徐州医学院,博士后

代表性研究成果和学术奖励情况

(1) Weng P, Zhang XT, Sheng Q, Tian WF, Chen JL, Yuan JJ, Zhang JR, Pang QF.Caveolin-1 scaffolding domain peptides enhance anti-inflammatory effect of heme oxygenase-1 through interrupting its interact with caveolin-1.Oncotarget. 2017 Mar 29. Epub ahead of print.

(2) Tian WF, Weng P, Sheng Q, Chen JL, Zhang P, Zhang JR, Du B, Wu MC, Pang QF, Chu JJ. Biliverdin Protects the Isolated Rat Lungs from Ischemia-reperfusion Injury via Antioxidative, Anti-inflammatory and Anti-apoptotic Effects.Chin Med J (Engl). 2017 Apr 5;130(7):859-865.

(3) Chen JL, Dai L, Zhang P, Chen W, Cai GS, Qi XW, Hu MZ, Du B,Pang QF. Methylene blue attenuates acute liver injury induced by paraquat in rats. Int Immunopharmacol, 2015, 28(1):808-812.

(4) Chu J, Zhang X, Jin L, Chen J, Du B,Pang Q. Protective effects ofcaffeic acid phenethyl ester against acute radiation-induced hepatic injury in rats. Environ Toxicol Pharmacol, 2015, 39(2):683-689.

(5) Tian ZG, Ji Y, Yan WJ, Xu CY, Kong QY, Han F, Zhao Y,Pang QF.Methylene blue protects against paraquat-induced acute lung injury in rats. IntImmunopharmacol., 2013, 17(2):309-313.

(6) Teng D,Pang QF, Yan WJ, Zhao Xin W, Xu CY. The harmfuleffect of prolonged high-dose methylprednisolone in acute lung injury.IntImmunopharmacol., 2013, 15(2):223-226.

(7) Li XJ, Liu DP, Chen HL, Pan XH, Kong QY,Pang QF. Lactoferrinprotects against lipopolysaccharide-induced acute lung injury in mice.IntImmunopharmacol., 2012,12(2):460-464.

(8) Hualin C, Wenli X, Dapeng L, Xijing L, Xiuhua P,Qingfeng P. The Anti-inflammatory Mechanism of Heme Oxygenase-1 Induced by Hemin in Primary Rat Alveolar Macrophages. Inflammation, 2012, 35(3):1087-1093.

(9)Pang QF, Lidong Dou, Xiuhua Pan, Si Zeng, Jun He, Wenli Xu, Yinming Zeng.Methylene chloride protects against cecal ligation and puncture-induced acute lunginjury by modulating inflammatory mediators. Int Immunopharmacol, 2010,10: 929-932.

三、团队成员简介

周乐源

江南大学附属医院放疗科副主任医师,复旦大学肿瘤学博士。江苏省医学会肿瘤放射治疗分会青年委员,江苏省免疫学会青年委员,2014/11~2015/5年在密歇根大学放疗科做访问学者。主要研究方向肝癌放射治疗及肝脏放射损伤、头颈部及泌尿生殖系统肿瘤放射治疗、肿瘤放疗增敏等。主持课题:国家自然科学基金青年基金“亚致死照射促进肝癌细胞侵袭转移潜能增高的机制及其干预的初步研究”(编号81301920, 2014~2016);参与课题:国家自然科学基金面上项目“长链非编码RNA-LOC154860在结直肠癌发生发展中的作用及机制研究”(编号81272299)。

工作、学习经历

2006/7-至今,附属医院肿瘤放疗科,主治医师、副主任医师、科主任助理

2014/11-2015/5,University of Michigan放疗科,访问学者

2009/9-2012/7,复旦大学肿瘤学博士

2003/9-2006/7,苏州大学肿瘤学硕士

1999/11-2003/8,江南大学附属医院病理科

王志强

江南大学附属医院胸外科副主任医师,中华医学会会员,江苏省抗癌协会食管癌专业委员会青年委员,无锡市全科医学委员会委员。发表论文30余篇,其中以第一作者/通信作者发表SCI论文6篇,中华核心论文3篇。2015年获江苏省新技术引进二等奖一项 (排名第一),2016年获实用新型专利一项 (排名第一)。长期从事肺癌、心肺保护的基础及临床研究和胸腔镜技术的临床应用。

工作、学习经历

2004/7-至今,江南大学附属医院胸心外科,副主任医师

2011/9-2014/7,南京医科大学,胸心外科博士,

2001/9-2004/7,武汉大学医学院外科学硕士,

1996/9-2001/7,三峡大学医学院,临床医学系学士

王元

江南大学附属医院妇产科副主任医师,妇产科主任助理,江南大学硕士研究生导师,指导硕士研究生2名。

工作、学习经历

1996/8-至今,江南大学附属医院妇产科,副主任医师,妇产科主任助理

2015/7-2015/9,美国纪念斯隆凯特琳癌症中心进修

2012/9-2015/6,苏州大学,妇产科专业博士

2001/9-2005/6,苏州大学,妇产科专业硕士

1991/9-1996/6,扬州大学医学院,妇产科学系,学士

田文芳

江南大学医学院讲师

工作、学习经历

2016/3-至今,江南大学医学院,讲师

2015/9-2016/3,南京医科大学基础医学院/心血管病转化医学协同创新中心,讲师

2010/9-2015/7,南京医科大学基础医学院,病理生理学系,博士,导师:徐涌

2006/9-2010/7,中国药科大学生命科学与技术学院,海洋药学专业,理学学士

四、团队代表性科研项目

序号

项目名称

项目来源

项目批准号

资助经费(万元)

项目起止期限

1

小窝蛋白脚手架区变异多肽解除HO-1活性内源性抑制的实验研究

国家自然科学基金

81270126

70

2013.01~16.12

2

亚致死照射促进肝癌细胞侵袭转移潜能增高的机制及其干预的初步研究

国家自然科学基金

81301920

25

2014.01~16.12

3

Myocardin在肝星状细胞激活中的转录调控及生物学意义

国家自然科学基金

81600487

17

2017.01~19.12

4

MRTF-A介导RhoJ基因转录的表观遗传机制及其在乳腺癌恶变中的病理生理学意义

国家自然科学基金

81702799

19

2018.01~20.12

5

小窝蛋白脚手架区变异多肽解除HO-1活性内源性抑制的实验研究

江南大学自主科研计划重点项目

JUSRP51412B

80

2014.01~16.12

6

血红素加氧酶-1促进肺泡巨噬细胞合成白介素-10的作用及机制

江苏省六大人才高峰

53301004

12

2011.01~14.12

7

miRNA-218通过靶向PXN调控宫颈癌的机制研究

无锡市卫生局科研立项项目

MS201417

3

2015.01~17.12

8

miRNA-218与宫颈癌放化疗敏感性的相关性研究

无锡市卫生局基妇处妇幼保健项目

FYKY201401

3

2015.01~17.12

9

microRNA-218通过靶向PXN调节宫颈癌放疗敏感性的研究

无锡市科技局

CSE31N1418

2

2014.07~17.06

五、团队代表性科研成果

(1) Chen JL, Dai L, Zhang P, Chen W, Cai GS, Qi XW, Hu MZ, Du B,Pang QF. Methylene blue attenuates acute liver injury induced by paraquat in rats. IntImmunopharmacol, 2015; 28(1):808-812.

(2) Chu J, Zhang X, Jin L, Chen J, Du B,Pang Q. Protective effects of caffeic acid phenethyl ester against acute radiation-induced hepatic injury in rats. Environ ToxicolPharmacol, 2015; 39(2):683-689.

(3) Tian ZG, Ji Y, Yan WJ, Xu CY, Kong QY, Han F, Zhao Y,Pang QF. Methylene blue protects against paraquat-induced acute lung injury in rats. Int Immunopharmacol, 2013; 17(2):309-313.

(4) Teng D,Pang QF, Yan WJ, Zhao Xin W, Xu CY. The harmful effect of prolonged high-dose methylprednisolone in acute lung injury. Int Immunopharmacol, 2013; 15(2):223-226.

(5) Li XJ, Liu DP, Chen HL, Pan XH, Kong QY,Pang QF. Lactoferrinprotects against lipopolysaccharide-induced acute lung injury in mice. Int Immunopharmacol, 2012; 12(2):460-464.

(6) Hualin C, Wenli X, Dapeng L, Xijing L, Xiuhua P,Qingfeng P. The Anti-inflammatory Mechanism of Heme Oxygenase-1 Induced by Hemin in Primary Rat Alveolar Macrophages. Inflammation, 2012; 35(3):1087-1093.

(7)Pang QF, Lidong Dou, Xiuhua Pan, Si Zeng, Jun He, Wenli Xu, Yinming Zeng. Methylene chloride protects against cecal ligation and puncture-induced acute lunginjury by modulating inflammatory mediators. International Immunopharmacology, 2010, 10: 929-932.

(8)Tian W, Fan Z, Li J, Hao C, Li M, Xu H, Wu X, Zhou B, Zhang L, Fang M, Xu Y, Myocardin-related transcription factor A (MRTF-A) plays an essential role in hepatic stellate cell activation by epigenetically modulating TGF-β signaling, Int J Biochem Cell Biol, 2016, 71: 35-43.

(9) Fang M, Fan Z,Tian W, Zhao Y, Li P, Xu H, Zhou B, Zhang L, Wu X, Xu Y. HDAC4 mediates IFN-γinduced disruption of metabolic homeostasis by repressing SIRT1 transcription in skeletal muscle cells, BBA-Gene Regul Mech, 2016, 1859(2): 294-305.

(10)Tian W, Xu Y. Decoding liver injury: A regulatory role for histone modifications.Int J Biochem Cell Biol, 2015, 67: 188-193.

(11)Tian W, Hao C, Fan Z, Weng X, Qin H, Wu X, Fang M, Chen Q, Shen A, Xu Y. Myocardin related transcription factor A programs epigenetic activation of hepatic stellate cells. J Hepatol, 2015, 62(1): 165-174.

(12)Tian W, Xu H, Fang F, Chen Q, Xu Y, Shen A. Brahma-related gene1 bridges epigenetic regulation of proinflammatory cytokine production to steatohepatitis in mice. Hepatology, 2013, 58(2): 576-188.

(13)Le-Yuan Zhou, Zhao-Chong Zeng, Jia Fan, et al. Radiotherapy treatment of adrenal gland metastases from hepatocellular carcinoma: clinical features and prognostic factors. BMC Cancer, 2014, 14:878.

(14)Zhou LY, Wang ZM, Gao YB, Wang LY, Zeng ZC. Stimulation of Hepatoma Cell Invasiveness and Metastatic Potential by Proteins Secreted from Irradiated Non-parenchymal Cells.Int J Radiat Oncol Biol Phys, 2012, 84(3):822-828.

(15) Zhi-ming Wang,Le-yuan Zhou, Bin-bin Liu, et al. Rat hepatic stellate cells alter the gene expression profile and promote the growth, migration, and invasion of hepatocellular carcinoma cells. Mol Med Rep, 2014, 10(4):1725-1733.

(16)Wang Z, Qiao Q, Chen M, Li X, Wang Z, Liu C, Xie Z. Mir-625 down-regulation promotes proliferation and invasion in esophageal cancer by targeting sox2. FEBS letters, 2014,588(6):915-921.

(17)Wang Z, Cai M, Weng Y, Zhang F, Meng D, Song J, Zhou H, Xie Z. Circulating macc1 as a novel diagnostic and prognostic biomarker for non small cell lung cancer.J Cancer Res Clin Oncol, 2015, 141(8):1353-61.

(18)Wang Z, Li Z, Wu C, Wang Y, Xia Y, Chen L, Zhu Q, Chen Y. Macc1overexpression predicts a poor prognosis for non-small cell lung cancer. Medicaloncology, 2014,31(1):790.

(19)Wang Z, Zhang J, Cheng Z, Li X, Wang Z, Liu C, Xie Z. Factors affecting major morbidity after video-assisted thoracic surgery for lung cancer. The Journal of surgical research, 2014, 192(2):628-634.

(20)Yuan Wang, Chaoying Hu, Ruofan Dong, Xiaoyan Huang, HaifengQiu. Platelet-derived Growth Factor-D Promotes Ovarian Cancer Invasion by Regulating Matrix Metalloproteinases 2 and 9,Asian Pacific J Cancer Prev, 2011(12): 3367-3370.

(21)Yuan Wang,Jin-Jin Yu,Ting Zhu,Ling Xu,Ming Xu,Yu-Zheng Huang, Hong Pu,Chun-Qing Yu.Analysis of diferentially expressed protein from primary and recurrent ovarian cancer serum.Asian Pacific J Tropical Medicine, 2012(5):573-576.

(22)Yuan Wang, Haifeng Qiu,Weixu Hu, Shaoru Li, Jinjin Yu.RPRD1B promotes tumor growth by accelerating the cell cycle in endometrial cancer. ONCOLOGY REPORT, 2014(31): 1389-1395.

(23)Yuan Wang,HaifengQiu,Weixu Hu, Shaoru Li, Jinjin Yu.Over-Expression of Platelet-Derived Growth Factor-D Promotes Tumor Growth and Invasion in Endometrial Cancer. Int J Mol Sci, 2014, 15, 4780-4794.

(24)Wang Yuan,Han Xiaoyun, QiuHaifeng, Li Jing, Hu Weixu,Dong Ruofan,Yu Jinjin, Shen Zongji. MicroRNA-218 Enhances the Radiosensitivity of Human Cervical Cancer via Promoting Radiation Induced Apoptosis. Int J Med Sci, 2014, 11(7): 691-696.

(25) Weng P, Zhang XT, Sheng Q, Tian WF, Chen JL, Yuan JJ, Zhang JR, Pang QF.Caveolin-1 scaffolding domain peptides enhance anti-inflammatory effect of heme oxygenase-1 through interrupting its interact with caveolin-1.Oncotarget. 2017 Mar 29. Epub ahead of print.

(26) Tian WF, Weng P, Sheng Q, Chen JL, Zhang P, Zhang JR, Du B, Wu MC, Pang QF, Chu JJ. Biliverdin Protects the Isolated Rat Lungs from Ischemia-reperfusion Injury via Antioxidative, Anti-inflammatory and Anti-apoptotic Effects.Chin Med J (Engl). 2017 Apr 5;130(7):859-865.

六、团队合影

442AF

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