博士，教授，博导

一、个人简介

朱一菲，博士，教授，博导。朱一菲博士基于细胞膜瞬时受体电位通道（TRP channel），开展心血管功能调控与心血管保护研究，在TRP离子通道蛋白与心血管慢病领域取得系列重要成果。相关研究近年来以第一作者或通讯作者身份发表在Circulation Research (2025)、Hypertension (2023)、Fundamental Research (2022)、Cardiovascular Research (2021)、Biochem Pharmacol (2025)、Oncogene (2019)、J Bio Chem (2019)、Pharmacol Res (2015)等高水平期刊。主持国家自然科学基金面上项目、国家自然科学基金青年项目、江苏省自然科学基金青年项目。

主要经历：2018年获香港中文大学生物医学哲学博士学位。2019年入职江南大学医学院。

二、研究领域

细胞膜瞬时受体电位通道（TRP channel）、心血管慢病。

三、荣誉奖励

江苏省“双创博士”（2020）

四、学术成果

（一）代表性项目

1.国家自然科学基金面上项目，82670549，2027/01-2030/12，主持

2.国家自然科学基金面上项目，82270461，2023/01-2026/12，主持

3.国家自然科学基金青年基金项目，82000291，2021/01-2023/12，主持

4.江苏省科技计划青年基金项目，BK20190596，2019/07-2022/06，主持

（二）代表性论文

1.Zhu Y, Chu Y, Lan Y, Wang S, Zhang Y, Liu Y, Wang X, Yu F, Ma X. Loss of Endothelial TRPC1 Induces Aortic Hypercontractility and Hypertension.Circ Res. 2025 Feb 6. doi: 10.1161/CIRCRESAHA.124.325574.

2.Zhu Y, Chu Y, Wang S, Tang J, Li H, Feng L, Yu F, Ma X. Vascular Smooth Muscle TRPV4 (Transient Receptor Potential Vanilloid Family Member 4) Channels Regulate Vasoconstriction and Blood Pressure in Obesity.Hypertension. 2023 Apr;80(4):757-770.

3.Yifei Zhu^#,Sheng Wang^#, Yuan Chu, Ka Zhang, Xin Wen, Lei Feng, Fan Yu, Xin Ma*, TRPC5 is essential in endothelium-dependent contraction of aorta from diet-induced obese mice,Fundamental Research, 2022;Volume 2, Issue 3,Pages 429-436,ISSN 2667-3258.

4.Yifei Zhu^#, Lei Wen^#, Sheng Wang^#, Ka Zhang, Yue Cui, Chi Zhang, Lei Feng, Fan Yu,Yongquan Chen, Ruxing Wang, Xin Ma*.Omega-3 fatty acids improve flow-induced vasodilation by enhancing TRPV4 in arteries from diet-induced obese mice.Cardiovasc Res. 2021 Nov 1;117(12):2450-2458.

5.Chu Y, Zhang Y, Chu C, Liu Y, Tang J, Yu F,Zhu Y*（唯一通讯作者）. Endothelial TRPV4 mitigates obesity-induced metabolic dysfunction via Ca2+-dependent eNOS phosphorylation.Int Immunopharmacol.2026 Aug 3;187:117202.

6.Chen J, Chu Y, Lan Y, Wan J, Zhang Y, Liu Y, Yu F, Feng L,Zhu Y*（唯一通讯作者）. TRPV4 maintains the contractile phenotype of VSMCs by regulating CPI-17.Biochem Pharmacol.2025 Jul 4:117107. doi: 10.1016/j.bcp.2025.117107

7.Yifei Zhu, Mingxu Xie, Zhaoyue Meng, Lai Kwok Leung, Franky Leung Chan, Xin Hu, Kailong Chi, Cuiling Liu, Xiaoqiang Yao*. Knockdown of TM9SF4 boosts ER stress to trigger cell death of chemoresistant breast cancer cells.Oncogene. 2019; 38: 5778-5791.

8.Yifei Zhu^#, Mengru Gao^#, Tingting Zhou^#, Mingxu Xie, Aiqin Mao, Lei Feng, Xiaoqiang Yao, Wing Tak Wong, Xin Ma*. The TRPC5 channel regulates angiogenesis and promotes recovery from ischemic injury in mice.J Biol Chem. 2019; 294: 28-37.

9.Yifei Zhu^#, Qiongxi Pan^#, Huan Meng^#, Yueshui Jiang^#, Aiqin Mao, Teng Wang, Dong Hua,Xiaoqiang Yao, Jian Jin, Ma Xin*. Enhancement of vascular endothelial growth factor release in long-term drug-treated breast cancer via transient receptor potential channel 5-Ca(2+)-hypoxia-inducible factor 1alpha pathway.Pharmacol Res. 2015; 93: 36-42.

五、联系方式

通讯地址：江苏省无锡市滨湖区蠡湖大道1800号江南大学

邮箱：yifeizhu@jiangnan.edu.cn