一、团队简介

病原性疾病是全球严峻的公共卫生挑战，持续威胁人类健康。病原体与宿主免疫系统的相互作用涉及病原体入侵识别、信号转导、免疫应答与逃逸。病原生物学团队立足上述关键科学问题，以疟原虫、华支睾吸虫、乙型肝炎病毒等代表性病原体为研究对象，系统开展以下方向的研究：

（1）病原体的感染入侵与致病机制；

（2）病原体诱导的免疫识别与应答机制；

（3）病原体的免疫逃逸与调控机制；

（4）病原性疾病的流行特征与防治策略；

（5）炎症及肿瘤的发生发展机制，以及天然产物的抗炎、抗肿瘤作用。

团队致力于从免疫调控与病原互作的全新视角，阐明感染性疾病的核心病理机制，为疾病防控、药物研发及临床转化提供科学支撑。

二、团队负责人简介

韩甦，江南大学医学院教授，博士生导师。2006年本科毕业于哈尔滨医科大学临床医学专业，2013年获病原生物学博士学位，之后进入中国疾病预防控制中心寄生虫病预防控制所博士后流动站开展研究工作。一直从事华支睾吸虫、疟原虫的致病机制及免疫识别应答研究。目前研究方向为（1）疟原虫入侵及免疫逃避机制（2）疟疾疫苗开发（3）华支睾吸虫病的肝胆损伤机制。目前已发表国内外研究论文30余篇，先后主持国家自然科学面上基金1项，国家自然科学青年基金1项，黑龙江省优秀青年基金1项，中国博士后基金1项，中国博士后特别资助基金1项等；另参与国家自然科学基金以及多项省级、市级课题项目。获黑龙江省医药卫生科学技术三等奖１项（第一名）。授权国家发明专利2项。

三、团队成员简介

邓超，江南大学医学院副教授，硕士生导师。主要研究方向为：外泌体对炎症的防治及其机制研究。主要包括（1）干细胞和其他来源外泌体对炎症性肠道疾病的调控作用及机制；（2）以外泌体作为药物载体实现靶向治疗的新型制剂研究。以第一作者或通讯作者在Gut、Journal of Controlled Release、Npj Precision Oncology、Journal of Colloid And Interface Science、International Journal of Pharmaceutics、International Journal of Biological Macromolecules等中科院1区和2区TOP期刊上发表SCI论文10余篇；主持和参与包括国家自然科学基金、江苏省科技支撑计划项目，江苏省产学研项目及企业合作项目10余项；授权国家发明专利10余项，其中国际发明专利1项；获得教育部高等学校科学技术进步奖二等奖2项，江苏省科学技术奖二等奖2项。

柳又祎，江南大学医学院副教授，硕士生导师，江苏省2020年“双创博士”。主要研究方向：HBV感染与肝癌发生发展机制，肝癌肿瘤免疫微环境。目前主持国家与江苏省自然科学基金各1项，国家博士后科学基金项目1项、无锡市“太湖之光”基础研究1项。近5年以第一作者或通讯作者发表SCI论文10余篇。

四、团队代表性科研项目

五、团队代表性科研成果

(1)Chao Deng, Haitian Fu, Jingying Shang, Jinghua Chen, Xin Xu. Dectin-1 mediates the immunoenhancement effect of the polysaccharide from Dictyophora indusiata.International Journal of Biological Macromolecules, 2018, 109: 369-374.

(2) Wang, Yalin; Lai, Li; Teng, Liping; Li, Yuhong; Cheng, Jianqing; Chen, Jinghua;Deng,Chao.Mechanism of the anti-inflammatory activity by a polysaccharide from Dictyophora indusiata in lipopolysaccharide-stimulated macrophages,International Journal of Biological Macromolecules, 2019, 126: 1158-1166.

(3) Wang, Yalin; Ji, Xingming; Yan, Meilin; Chen, Xue; Kang, Mingzhu; Teng, Liping; Wu, Xiaotao; Chen, Jinghua;Deng, Chao. Protective effect and mechanism of polysaccharide from Dictyophora indusiata on dextran sodium sulfate-induced colitis in C57BL/6 mice,International Journal of Biological Macromolecules, 2019, 140: 973-984.

(4)Chao Deng; Yiwei Hu; Mariana Conceição; Matthew J.A. Wood; Hongyao Zhong; Yan Wang; Ping Shao; Jinghua Chen; Lipeng Qiu; Oral delivery of layer-by-layer coated exosomes for colitis therapy,Journal of Controlled Release, 2023, 354: 635-650.

(5) Zhong, H.; Zhang, H.; Hu, Y.; He, S.; Qu, H.; He, J.; Chen, J.; Chen, J.; Zhang, L.;Deng, C. Self-assembled micelle derived from pterostilbene ameliorate acute inflammatory bowel disease.International Journal of Pharmaceutics, 2023, 630: 122420.

(6)Deng, C; Zhang, HX; Li, YX; Cheng, XY; Liu, YY; Huang, SB; Cheng, JQ; Chen, H; Shao, P; Jiang, B; Wang, XW; Wang, KW; Exosomes derived from mesenchymal stem cells containing berberine for ulcerative colitis therapy,Journal of Colloid And Interface Science,2024, 671: 354-373.

(7) Kewei Wang; Chenjun Xie; Zheng Ding; Ting Shan; Zhangfeng Zhong; Fenglai Yuan; Junjie Wu; Zhengdong Yuan; Chengjia Qian; Lihua Yu; Yankui Liu; Jianqing Cheng; Qinglin Zhang; Wei Liu; YongZhao; Jianfeng Huang; Wenzhe Zhang; Qian Yin; Boyu Gao; Jieqing Hou; Jichao Wang; Jie Mei;Chao Deng. PDE5A+ cancer- associated ffbroblasts enhance immune suppression in gastric cancer, Gut, 2025, 0: 1-16.

(8)Chao Deng; Chenjun Xie; Zixi Li; Jie Mei; Kewei Wang; Multi-omics analysis identifies

diagnostic circulating biomarkers and potential therapeutic targets, revealing IQGAP1 as an

oncogene in gastric cancer, npj precision oncology, 2025, (9): 15-23.

(9)Chao Deng；Xinyi Cheng；Qingying Sun；Yeliaman Yeerbolati；Rui Zheng；Youyi Liu；

Ying Ya; Yanbing Shen; Kewei Wang; Jianfeng Huang. Oral delivery of chitosan/hyaluronic-acid-

coated milk-derived exosomes for ulcerative-colitis amelioration, International Journal of Pharmaceutics: X, 2025, 10:100447.

（10）Su Han,Jie Wan,Xiaoli Zhang,Jian Ding,Xiang Li,Yang Cheng,Yifan Sun,Zhenli Xu,Jianlin Wu,Rui Chen. Proteomic profiling of spleen in rat infected with clonorchis sinensis using liquid chromatography tandem mass spectrometry analysis.Acta Trop.2025 Mar 22:265:107594. doi: 10.1016/j.actatropica.2025.107594.

(11)Zhenli Xu , Shiwen Hua , Jian Ding , Xinyi Hu , Rui Chen , Yang Cheng,Su Han*. Absolute quantitative lipidomics of Clonorchis sinensis-infected rats reveals key alterations in metabolic pathways.J Chromatogr B Analyt Technol Biomed Life Sci .2025 Jun 6:1263:124672. doi: 10.1016/j.jchromb.2025.124672. Online ahead of print.

(12)Xin Ling1†, Feng Chen2†, Sui Xu3†, Yuan Tan4, Yifan Sun1,Su Han1*, Qiubo Wang5* and Yang Cheng. Immunogenicity and gene polymorphism analysis of Plasmodium ovale wallikeri glycosylphosphatidylinositol-anchored micronemal antigen (GAMA) .Malaria Journal2025 Nov 4;24(1):372. doi: 10.1186/s12936-025-05603-3.

(13)Shiwen Hua a,1, Xiang Li b,c,1, Zhenli Xu a, Rui Chen d, Qinghua Wu e, Wenge Yang e, Yun Tao e，Shanshan Duan b, Jian Ding b, Jie Wan a, Jingjie Lei a, Yang Cheng a, Yifan Sun a,e,f,g, Youyi Liu a,Su Hana,b,* . Bile acid alterations in biliary obstruction patients with clonorchiasis.Acta Tropica274 (2026) 107989 https://doi.org/10.1016/j.actatropica.2026.107989

(14)Yifan Sun，Zhe Chen，Chenyan Du，Yao Lei, Jian Li，Hangye Zhang，Xuan Huang，Bo Wang，Shenghuan Zuo，Zhiyue Lv，Jianping Cao，Su Han* ,Yang Cheng*. Interaction of Plasmodium yoelii tryptophan-rich antigen 7 with CD71 on macrophage membrane regulates host inflammatory response.iScience.Volume 29, Issue 4, 17 April 2026, 115468 https://doi.org/10.1016/j.isci.2026.115468

(15) Wu, X.; Wang, B.; Hou, Y.; Fang, Y.; Jiang, Y.; Song, Y.;Liu, Y*.; Jin, C*. PFKM-Mediated Glycolysis: A Pathway for ASIC1 to Enhance Cell Survival in the Acidic Microenvironment of Liver Cancer.Biomolecules2025, 15, 356, doi:10.3390/biom15030356.

(16) Qu, H.; He, S.; He, J.; Wang, C.; Wang, K.; Deng, C.; Liu, T.; Hua, H.;Liu, Y. Potential Future Therapeutic Application of Mesenchymal Stem Cell-Derived Exosomes in Ulcerative Colitis.CSCR2024, 20, doi:10.2174/011574888X340609241220053638.

(17)Liu, Y.; Chen, X.; Zhang, X.; Guo, J.; Tang, Y.; Jin, C.; Wu, M. CCL28 Promotes Progression of Hepatocellular Carcinoma through PDGFD-Regulated MMP9 and VEGFA Pathways.Discover Oncology2024, 15, 324, doi:10.1007/s12672-024-01185-9.

(18)Liu, Y.; Wang, B.; Cheng, Y.; Fang, Y.; Hou, Y.; Mao, Y.; Wu, X.; Jiang, D.; He, Y.; Jin, C. ASIC1 Promotes Migration and Invasion of Hepatocellular Carcinoma via the PRKACA/AP-1 Signaling Pathway.Carcinogenesis2024, 45, 399–408, doi:10.1093/carcin/bgae008.

(19)Liu, Y.; Guo, J.; Liu, C.; Chen, X.; Tang, Y.; Wu, M.; Huang, J. Unveiling Pharmacological Targets of Rihimaside C for Radiation-Induced Lung Injury: An in Silico and Experimental Integrated Approach.Journal of Traditional and Complementary Medicine2024, doi:10.1016/j.jtcme.2024.05.009.

专利：

(1)Preparation method for exosome-loaded polymer for use in oral colon-targeting drug delivery, 2025.3.19, GB2616153 (英国专利)

(2)一种用于口服结肠靶向给药的外泌体-聚合物杂化纳米颗粒的制备方法及应用，2024.3.1，ZL202210660399.0

(3)一种负载外泌体用于口服结肠靶向给药的层层自组装聚合物的制备, 2021.9.24，ZL202011589485.4

(4)一种包载干细胞的口服结肠靶向自主装聚合物的制备方法，2021.11.23，ZL202011503857.7

(5)一种注射用多功能复合型水凝胶及其制备方法, 2020.11.6, ZL201810185988.1