一、个人简介 刘焕良,博士研究生,副教授,硕士生导师 主要经历: 2017/03–2021/12东南大学卫生毒理学 博士 2019/08–2019/11韩国建国大学环境与健康学 国际交换生 2021/02–2021/10瑞士洛桑联邦理工学院综合系统生理学 国家公派联合培养博士生 2022/03-至今江南大学医学院副教授 二、研究领域 1.环境新兴污染物所致的跨代神经毒性评价及分子机理探究 2.环境新兴污染物所致的跨代生殖毒性评价及分子机理探究 3.表观遗传在适应性应激反应途径(如线粒体未折叠蛋白反应)中的调节机制 三、学术成果 (一)代表性项目 1.秀丽线虫组蛋白甲基转移酶MET-2介导LIN-3/LET-23/LIN-1信号轴参与纳米聚苯乙烯跨代生殖毒效应的分子机制研究,国家自然科学基金青年项目,30万,42207328,2023-2025,主持 2.环境剂量纳米聚苯乙烯致秀丽线虫跨代生殖毒效应及组蛋白甲基转移酶MET-2介导的分子调控机制研究,江苏省自然科学基金青年项目,20万,BK20221089,2022-2025,主持 3.秀丽线虫种系EGF信号参与调控环境剂量纳米聚苯乙烯跨代生殖毒效应的分子机制研究,中央高校基本科研计划,8万,2022-2024,主持 (二)代表性论文 1.Liu H,Wu Y, Wang Z. Long-term exposure to polystyrene nanoparticles at environmentally relevant concentration causes suppression in heme homeostasis signal associated with transgenerational toxicity induction inCaenorhabditis elegans. (J Hazard Mater. 2023 Oct 5;459:132124.IF=12.2.中科院一区) 2.Liu H, Tian L, Qu M, Wang D. Acetylation regulation associated with the induction of protective response to polystyrene nanoparticles inCaenorhabditis elegans. (J Hazard Mater.2021 Jun 5;411:125035.IF=12.2.中科院一区) 3.Liu H, Tan X, Li X, Wu Y, Lei S, Wang Z. Amino-modified nanoplastics at predicted environmental concentrations cause transgenerational toxicity through activating germline EGF signal inCaenorhabditis elegans. (Sci Total Environ.2024 Oct 15;947:174766. IF=8.2.中科院一区) 4.Liu H, Tan X, Wu Y, Li X, Hu Z, Lei S, Fan W, Wang Z. Long-term exposure to 6-PPD quinone at environmentally relevant concentrations causes neurotoxicity by affecting dopaminergic, serotonergic, glutamatergic, and GABAergic neuronal systems inCaenorhabditis elegans. (Sci Total Environ. 2024 Apr 20;922:171291. IF=8.2.中科院一区) 5.Liu H, Tian L, Wang S, Wang D. Size-dependent transgenerational toxicity induced by nanoplastics in nematodeCaenorhabditis elegans. (Sci Total Environ.2021 Oct 10;790:148217.IF=8.2.中科院一区) 6.Liu H, Zhang R, Wang D. Response of DBL-1/TGF-β signaling-mediated neuron-intestine communication to nanopolystyrene in nematodeCaenorhabditis elegans. (Sci Total Environ. 2020 Nov 25;745:141047.IF=8.2.中科院一区) 7.Liu H, Kwak JI, Wang D, An YJ. Multigenerational effects of polyethylene terephthalate microfibers inCaenorhabditis elegans.(Environ Res. 2021Feb;193:110569.IF=7.7.中科院二区) 8.Liu H, Guo D, Kong Y, Rui Q, Wang D. Damage on functional state of intestinal barrier by microgravity stress in nematodeCaenorhabditis elegans.(Ecotoxicol Environ Saf. 2019 Nov 15;183:109554.IF=6.2.中科院二区) 9.Liu H, Zhao Y, Hua X, Wang D. Induction of transgenerational toxicity is associated with the activated germline insulin signals in nematodes exposed to nanoplastic at predicted environmental concentrations. (Ecotoxicol Environ Saf. 2022 Sep 15;243:114022.IF=6.2.中科院二区) 10.Liu H, Zhao Y, Bi K, Rui Q, Wang D. Dysregulatedmir-76mediated a protective response to nanopolystyrene by modulating heme homeostasis related molecular signaling in nematodeCaenorhabditis elegans. (Ecotoxicol Environ Saf. 2021 Apr 01;212:112018.IF=6.2.中科院二区) 四、联系方式 通讯地址:江苏省无锡市蠡湖大道1800号江南大学无锡医学院 邮箱:huanliangliu@jiangnan.edu.cn |